Isolation of Pregnane-3(a)-ol-20-one from the Hydrolysis Products of 'Sodium Pregnanediol Glucuronidate'
نویسندگان
چکیده
منابع مشابه
Enzymatic Hydrolysis of Urinary Sodium Pregnasediol Glucuronidate to Free Pregnanediol*
The available evidence suggests that most of the steriod hormone endproducts which are eliminated from the body by way of the urine are conjugated with an inorganic or organic acid. This conjugation presumably facilitates their transportation and excretion by rendering them soluble in water or urine. Examples of such conjugated steroids which have been isolated from urine as sulfates are andros...
متن کاملExcretion of Sodium Pregnanediol Glucuronidate
Venning and Browne (1 to 7) have shown that sodium pregnanediol glucuronidate is excreted in urine of human pregnancy in concentrations which become increasingly higher as gestation approaches term. Although this demonstration has been repeatedly confirmed (8 to 16), relatively few workers have studied the precise levels and ranges of normal excretion, or have secured long-continued records of ...
متن کاملThe Separation of Non-ketonic and Ketonic Sodium Glucuronidates from the 'Sodium Pregnanediol Glucuronidate' of Human Pregnancy Urine: the Isolation of Pure Sodium
It has recently been shown (Marrian & Gough, 1946 a, b) that the 'sodium pregnanediol glucuronidate' ('NaPG') prepared from human pregnancy urine by the method of Venning & Browne (1936) contains about 20% of a water-soluble derivative of pregnan-3(o)-ol-20-one which cannot be removed by repeated recrystallization from 90% (v/v) aqueous ethanol or by repeated precipitation from 50% (v/v) aqueou...
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15 صفحه اولThe Separation and Quantitative Estimation of Pregnane- 3a, l?~r, 20,~triol, Pregnane-3a ,17a, ZOa-trio14 l-one, and other Urinary Acetaldehydogenic Steroids*
The quantitative estimation of urinary 5P-pregnane-3&, 17a, 2Ocr-trio1 has become of interest, since it is frequently excreted in excessive amounts by patients with adrenocortical hyperplasia or adrenal tumors (reviewed (1)). The related 11-ketosteroid, 5&pregnane-Sa!, 17a, 20a-triol-11-one is often of greater biochemical interest since it has been isolated and estimated so far only in the urin...
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ژورنال
عنوان ژورنال: Nature
سال: 1946
ISSN: 0028-0836,1476-4687
DOI: 10.1038/157438b0